Why Kidneys Fail in ADPKD

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common type in PKD. As people with ADPKD usually begin to develop symptoms at age 30~40, it is also known as Adult PKD. More than half of people with ADPKD develop Renal Failure by age 60. Why kidneys fail?
ADPKD is featured with numerous cysts growing on kidneys. These cysts have been existed in kidneys since they are born. When they are young, the cysts are small so they do not cause symptoms at all.
However, with age, the cysts will increase both in size and number. If uncontrolled, the cysts will enlarge constantly to oppress the surrounding nephrons thus resulting in renal ischemia and anoxia. Moreover, more and more healthy nephrons are replaced with enlarged cysts. The renal fibrosis is initiated and kidneys begin to fail gradually.
However, not all people with ADPKD will develop Renal Failure. If they can receive proper treatment before renal insufficiency occurs, they will be able to avoid Renal Failure completely. Maybe you will say there is no cure for PKD. Yes, you are right. ADPKD is a genetic disease. It is not possible for us to change the gene problem in present medicine. However, it is possible for us to control the enlargement of renal cysts.
The cysts enlargement results from the increased secretion of cystic fluid by the epithelial cells of the cysts. If the cells are inactivated, they will stop growing.
If more blood and oxgen is applied to kidneys, the renal fibrosis will be inhibited. If so, the renal function will stop declining.
The therapeutic goals have been achieved in the present medicine area. The patients with ADPKD should change the conventional opinion on the treatment of the disease and find a better alternative method to treat the disease.