How does PKD cause Renal Failure?

Polycystic Kidney Disease (PKD) is a genetic kidney disorder. Although there is no cure for PKD yet, early intervention and treatment can improve the individuals’ health and make the avoid developing Renal Failure.
How does PKD cause Renal Failure?
PKD is featured by numerous cysts usually growing on both kidneys. With age, the cysts will increase both in size and number. The cysts will oppress the surrounding healthy nephrons thus resulting in renal ischemia and anoxia. Just like people, if the nephrons can not get sufficient oxgen supply, they will die. Finally, the kidneys will fail completely. The completely necrotic kidneys are just like hard stones so the blood can not pass through them at all.